{"id":12,"date":"2009-07-06T13:33:24","date_gmt":"2009-07-06T13:33:24","guid":{"rendered":"http:\/\/evperception.com\/blog\/2009\/07\/06\/OsteoOdontoKeratoprosthesis.aspx"},"modified":"2009-07-06T13:33:24","modified_gmt":"2009-07-06T13:33:24","slug":"osteo-odonto-keratoprosthesis","status":"publish","type":"post","link":"http:\/\/evperception.com\/blog\/osteo-odonto-keratoprosthesis\/","title":{"rendered":"Osteo-Odonto-Keratoprosthesis"},"content":{"rendered":"<p><H3 id=siteSub>From Wikipedia, the free encyclopedia<\/H3><br \/>\n<DIV id=contentSub><\/DIV><br \/>\n<DIV id=jump-to-nav>&nbsp;<\/DIV><br \/>\n<DIV><STRONG><EM>NB: With links to wikipedia<\/EM><\/STRONG><\/DIV><br \/>\n<DIV>&nbsp;<\/DIV><!-- start content --><br \/>\n<P><B>Osteo-Odonto-Keratoprosthesis<\/B> (OOKP) is a medical procedure to restore vision in the most severe cases of corneal and ocular surface patients. It includes removal of a tooth from the patient or a donor.<SUP id=cite_ref-0 class=reference><A href=\"http:\/\/en.wikipedia.org\/wiki\/Osteo-Odonto-Keratoprosthesis#cite_note-0\"><SPAN>[<\/SPAN>1<SPAN>]<\/SPAN><\/A><\/SUP> After this, a lamina of tissue cut from the tooth is drilled and the hole is fitted with optics. The lamina is grown in the patients&#8217; cheek for a period of months and then is implanted upon the eye.<SUP id=cite_ref-NDC_1-0 class=reference><A href=\"http:\/\/en.wikipedia.org\/wiki\/Osteo-Odonto-Keratoprosthesis#cite_note-NDC-1\"><SPAN>[<\/SPAN>2<SPAN>]<\/SPAN><\/A><\/SUP><\/P><br \/>\n<H2><SPAN class=mw-headline><\/SPAN>&nbsp;<\/H2><br \/>\n<H2><SPAN class=mw-headline><FONT size=3>Indications and prognosis<\/FONT><\/SPAN><\/H2><br \/>\n<P>An operation to graft the OOKP is undertaken in severe <A title=Pemphigoid href=\"http:\/\/en.wikipedia.org\/wiki\/Pemphigoid\">pemphigoid<\/A>, <A title=\"Chemical burn\" href=\"http:\/\/en.wikipedia.org\/wiki\/Chemical_burn\">chemical burns<\/A>, <A class=mw-redirect title=\"Stevens-Johnson syndrome\" href=\"http:\/\/en.wikipedia.org\/wiki\/Stevens-Johnson_syndrome\">Stevens-Johnson syndrome<\/A>, <A title=Trachoma href=\"http:\/\/en.wikipedia.org\/wiki\/Trachoma\">trachoma<\/A>, <A title=\"Toxic epidermal necrolysis\" href=\"http:\/\/en.wikipedia.org\/wiki\/Toxic_epidermal_necrolysis\">Lyell syndrome<\/A> and multiple <A class=mw-redirect title=\"Corneal graft\" href=\"http:\/\/en.wikipedia.org\/wiki\/Corneal_graft\">corneal graft<\/A> failure.<SUP id=cite_ref-pmid18706878_2-0 class=reference><A href=\"http:\/\/en.wikipedia.org\/wiki\/Osteo-Odonto-Keratoprosthesis#cite_note-pmid18706878-2\"><SPAN>[<\/SPAN>3<SPAN>]<\/SPAN><\/A><\/SUP><\/P><br \/>\n<P>There is a significant risk of anatomical failure of lamina in the long term, estimated at about 19% in a small study,<SUP id=cite_ref-pmid18511541_3-0 class=reference><A href=\"http:\/\/en.wikipedia.org\/wiki\/Osteo-Odonto-Keratoprosthesis#cite_note-pmid18511541-3\"><SPAN>[<\/SPAN>4<SPAN>]<\/SPAN><\/A><\/SUP> with the main risks being laminar <A title=Resorption href=\"http:\/\/en.wikipedia.org\/wiki\/Resorption\">resorption<\/A>, particularly in <A title=Allograft href=\"http:\/\/en.wikipedia.org\/wiki\/Allograft\">allografts<\/A>, and <A title=Glaucoma href=\"http:\/\/en.wikipedia.org\/wiki\/Glaucoma\">glaucoma<\/A>. Another, bigger study comparing OOKP with the lesser known Osteo-Keratoprosthesis (OKP) in 145 and 82 patients and follow-up terms up to 10 years yielded following statistics:<\/P><br \/>\n<UL><br \/>\n<LI>10-year anatomical survival: 66% for OOKP and 47% for OKP,<br \/>\n<LI>2-year functional survival: 63% for OOKP and 49% for OKP,<br \/>\n<LI>10-year functional survival: 38% for OOKP and 17% for OKP, <\/LI><\/UL><br \/>\n<P>with functional survival defined as best corrected visual acuity above 0.05.<SUP id=cite_ref-pmid18491123_4-0 class=reference><A href=\"http:\/\/en.wikipedia.org\/wiki\/Osteo-Odonto-Keratoprosthesis#cite_note-pmid18491123-4\"><SPAN>[<\/SPAN>5<SPAN>]<\/SPAN><\/A><\/SUP> A long-term study of 181 patients puts the chances of retaining an intact OOKP after 18 years at 85%.<SUP id=cite_ref-pmid16219722_5-0 class=reference><A href=\"http:\/\/en.wikipedia.org\/wiki\/Osteo-Odonto-Keratoprosthesis#cite_note-pmid16219722-5\"><SPAN>[<\/SPAN>6<SPAN>]<\/SPAN><\/A><\/SUP><\/P><br \/>\n<P><A id=Procedure name=Procedure><\/A><\/P><br \/>\n<H2><SPAN class=mw-headline><FONT size=3><\/FONT><\/SPAN>&nbsp;<\/H2><br \/>\n<H2><SPAN class=mw-headline><FONT size=3>Procedure<\/FONT><\/SPAN><\/H2><br \/>\n<P>OOKP is a complex two stage Operation which was pioneered in Italy in the 1963 by professor Strampelli.<SUP id=cite_ref-pmid1390492_6-0 class=reference><A href=\"http:\/\/en.wikipedia.org\/wiki\/Osteo-Odonto-Keratoprosthesis#cite_note-pmid1390492-6\"><SPAN>[<\/SPAN>7<SPAN>]<\/SPAN><\/A><\/SUP><\/P><br \/>\n<P><B>Stage 1<\/B> of the surgery involves 5 separate procedures:<\/P><br \/>\n<OL><br \/>\n<LI>The eye is opened up and the entire inner surface of the eyelids, corneal surface and all scar tissue is removed<br \/>\n<LI>Inner mucosal lining of the cheek is transplanted onto the new surface of the eye<br \/>\n<LI>A <A title=Canine href=\"http:\/\/en.wikipedia.org\/wiki\/Canine\">canine<\/A> or <A title=Premolar href=\"http:\/\/en.wikipedia.org\/wiki\/Premolar\">premolar<\/A> tooth and part of the adjacent bone and ligaments are removed<br \/>\n<LI>A bolt-shaped structure is fashioned from the tooth-bone complex which is fitted with a plastic optical cylinder<br \/>\n<LI>The tooth-bone-cylinder complex is implanted into the patient&#8217;s cheek to grow a new blood supply <\/LI><\/OL><br \/>\n<P><B>Stage 2<\/B> (about 4 months later) involves 2 separate procedures:<\/P><br \/>\n<OL><br \/>\n<LI>The cheek mucosal lining over the eye is opened and the inner contents of the eye are removed<br \/>\n<LI>The tooth-bone-cylinder complex is removed from the cheek and inserted into the eye, the mucosal cheek lining is replaced over the implant. <\/LI><\/OL><br \/>\n<P>At the end of the procedure, light can now enter through the plastic cylinder, and the patient is able to see through this cylinder with good vision.<SUP id=cite_ref-NDC_1-1 class=reference><A href=\"http:\/\/en.wikipedia.org\/wiki\/Osteo-Odonto-Keratoprosthesis#cite_note-NDC-1\"><SPAN>[<\/SPAN>2<SPAN>]<\/SPAN><\/A><\/SUP><\/P><\/p>\n","protected":false},"excerpt":{"rendered":"<p>From Wikipedia, the free encyclopedia &nbsp; NB: With links to [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-12","post","type-post","status-publish","format-standard","hentry","category-kiss-and-ride"],"_links":{"self":[{"href":"http:\/\/evperception.com\/blog\/wp-json\/wp\/v2\/posts\/12","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/evperception.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/evperception.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/evperception.com\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/evperception.com\/blog\/wp-json\/wp\/v2\/comments?post=12"}],"version-history":[{"count":0,"href":"http:\/\/evperception.com\/blog\/wp-json\/wp\/v2\/posts\/12\/revisions"}],"wp:attachment":[{"href":"http:\/\/evperception.com\/blog\/wp-json\/wp\/v2\/media?parent=12"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/evperception.com\/blog\/wp-json\/wp\/v2\/categories?post=12"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/evperception.com\/blog\/wp-json\/wp\/v2\/tags?post=12"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}